[HTML][HTML] Alzheimer's disease as a viral disease: Revisiting the infectious hypothesis

F Bruno, P Abondio, R Bruno, L Ceraudo… - Ageing research …, 2023 - Elsevier
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …

Overwhelming evidence for a major role for herpes simplex virus type 1 (HSV1) in Alzheimer's disease (AD); underwhelming evidence against

RF Itzhaki - Vaccines, 2021 - mdpi.com
This review describes investigations of specific topics that lie within the general subject of
HSV1's role in AD/dementia, published in the last couple of years. They include studies on …

Human herpesviruses 6A and 6B in brain diseases: association versus causation

AL Komaroff, PE Pellett, S Jacobson - Clinical microbiology …, 2020 - Am Soc Microbiol
SUMMARY Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B),
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …

[HTML][HTML] Evidence supportive of a bacterial component in the etiology for Alzheimer's disease and for a temporal-spatial development of a pathogenic microbiome in …

Y Moné, JP Earl, JE Król, A Ahmed, B Sen… - Frontiers in cellular …, 2023 - frontiersin.org
Background Over the last few decades, a growing body of evidence suggests a role for
various infectious agents in Alzheimer's Disease (AD) pathogenesis. Despite diverse …

The viral hypothesis: how herpesviruses may contribute to Alzheimer's disease

M Wainberg, T Luquez, DM Koelle, B Readhead… - Molecular …, 2021 - nature.com
The hypothesis that infectious agents, particularly herpesviruses, contribute to Alzheimer's
disease (AD) pathogenesis has been investigated for decades but has long engendered …

The Role of Human Herpesvirus 6 Infection in Alzheimer's Disease Pathogenicity—A Theoretical Mosaic

C Romanescu, TG Schreiner, I Mukovozov - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative disorder generally affecting older adults, is
the most common form of dementia worldwide. The disease is marked by severe cognitive …

The electronic tree of life (eToL): a net of long probes to characterize the microbiome from RNA-seq data

X Hu, JG Haas, R Lathe - BMC microbiology, 2022 - Springer
Background Microbiome analysis generally requires PCR-based or metagenomic shotgun
sequencing, sophisticated programs, and large volumes of data. Alternative approaches …

Controversial role of herpesviruses in Alzheimer's disease

R Rizzo - PLoS pathogens, 2020 - journals.plos.org
The controversial hypothesis that microbes might trigger Alzheimer's disease (AD) has been
debated for decades. Around 30 years ago, researchers in the United Kingdom discovered …

The remarkable complexity of the brain microbiome in health and disease

X Hu, CA Mckenzie, C Smith, JG Haas, R Lathe - biorxiv, 2023 - biorxiv.org
Microbes in human brain and their potential contribution to neurodegenerative conditions
such as Alzheimer's disease (AD) have long been debated. We recently developed a new …

Activation of endogenous retrovirus, brain infections and environmental insults in neurodegeneration and Alzheimer's disease

F Licastro, E Porcellini - International Journal of Molecular Sciences, 2021 - mdpi.com
Chronic neurodegenerative diseases are complex, and their pathogenesis is uncertain.
Alzheimer's disease (AD) is a neurodegenerative brain alteration that is responsible for most …