DNA methylation profiling: an emerging paradigm for cancer diagnosis
A Papanicolau-Sengos, K Aldape - Annual Review of Pathology …, 2022 - annualreviews.org
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
[HTML][HTML] O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
W Yu, L Zhang, Q Wei, A Shao - Frontiers in oncology, 2020 - frontiersin.org
Chemoresistance has been a significant problem affecting the efficacy of drugs targeting
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
[HTML][HTML] A review of newly diagnosed glioblastoma
B Oronsky, TR Reid, A Oronsky, N Sandhu… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a
dismal prognosis. The current mainstay of treatment involves maximally safe surgical …
dismal prognosis. The current mainstay of treatment involves maximally safe surgical …
[HTML][HTML] A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) for over a decade,
but its treatment benefits are limited by acquired resistance, a process that remains …
but its treatment benefits are limited by acquired resistance, a process that remains …
MGMT testing—the challenges for biomarker-based glioma treatment
Many patients with malignant gliomas do not respond to alkylating agent chemotherapy.
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
ME Hegi, AC Diserens, T Gorlia… - … England Journal of …, 2005 - Mass Medical Soc
Background Epigenetic silencing of the MGMT (O6-methylguanine–DNA methyltransferase)
DNA-repair gene by promoter methylation compromises DNA repair and has been …
DNA-repair gene by promoter methylation compromises DNA repair and has been …
Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents
M Esteller, J Garcia-Foncillas, E Andion… - … England Journal of …, 2000 - Mass Medical Soc
Background The DNA-repair enzyme O 6-methylguanine-DNA methyltransferase (MGMT)
inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a …
inhibits the killing of tumor cells by alkylating agents. MGMT activity is controlled by a …
Genetic pathways to primary and secondary glioblastoma
H Ohgaki, P Kleihues - The American journal of pathology, 2007 - Elsevier
Glioblastoma is the most frequent and most malignant human brain tumor. The prognosis
remains very poor, with most patients dying within 1 year after diagnosis. Primary and …
remains very poor, with most patients dying within 1 year after diagnosis. Primary and …
Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT …
Resistance to alkylating agents via direct DNA repair by O6-methylguanine
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
Inactivation of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is a Common Event in Primary Human Neoplasia
The DNA repair protein O 6-methylguanine DNA methyltransferase (MGMT) removes alkyl
adducts from the O 6 position of guanine. MGMT expression is decreased in some tumor …
adducts from the O 6 position of guanine. MGMT expression is decreased in some tumor …