Background Africa is facing a rapidly growing chronic non-communicable disease burden
whilst at the same time experiencing continual high rates of infectious disease. It is well …

Objective: Alterations in glucose and lipid metabolism, lactic acidemia, bone disorders, and
abnormal body fat distribution have been recognized recently as frequent complications …

The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and
subsequent gene targeting studies in mice provided strong evidence that LXR plays a …

A commonly cited cause of poor adherence to highly active antiretroviral therapy (HAART) is
adverse drug reactions. Short-term adverse effects are potential threats to successful …

Human immunodeficiency virus (HIV) infection is a major global health problem. Recently,
combination therapy including HIV-1 protease inhibitors (PIs) has dramatically improved the …

Background Therapy with HIV protease inhibitors (PI) has been associated with
hyperglycemia, hyperlipidemia and changes in body composition. It is unclear whether …

Objective To provide population-based estimates of the prevalence of lipodystrophy
syndrome and constituent symptoms and to identify correlates of prevalent symptomology …

Background: Therapy with HIV protease inhibitors (PI) has been shown to worsen glucose
and lipid metabolism, but whether these changes are caused by direct drug effects, changes …

Highly active antiretroviral therapy (HAART) refers to a broad category of treatment regimens
usually comprised of three or more antiretroviral drugs that, in previously untreated HIV-1 …

Mortality rates in the HIV-infected patient population have decreased with the advent of
highly active antiretroviral therapy (HAART) for the treatment of AIDS. Due to the chronic …