High-intensity focused ultrasound: a review of mechanisms and clinical applications

VS Bachu, J Kedda, I Suk, JJ Green, B Tyler - Annals of biomedical …, 2021 - Springer
Abstract High Intensity Focused Ultrasound (HIFU) is an emerging and increasingly useful
modality in the treatment of cancer and other diseases. Although traditional use of …

Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications

MB Moravek, P Yin, M Ono, JS Coon V… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Uterine leiomyoma is the most common benign tumor in women and is
thought to arise from the clonal expansion of a single myometrial smooth muscle cell …

Treatment of uterine fibroid symptoms with relugolix combination therapy

A Al-Hendy, AS Lukes, AN Poindexter III… - … England Journal of …, 2021 - Mass Medical Soc
Background Uterine fibroids are a common cause of heavy menstrual bleeding and pain.
Treatment with the combination of relugolix (an oral gonadotropin-releasing hormone …

Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

M Messina, SB Mejia, A Cassidy… - Critical Reviews in …, 2022 - Taylor & Francis
Soybeans are a rich source of isoflavones, which are classified as phytoestrogens. Despite
numerous proposed benefits, isoflavones are often classified as endocrine disruptors, based …

The mechanism and function of epigenetics in uterine leiomyoma development

Q Yang, A Mas, MP Diamond… - Reproductive …, 2016 - journals.sagepub.com
Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors,
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …

Impact of preoperative anaemia and blood transfusion on postoperative outcomes in gynaecological surgery

T Richards, KM Musallam, J Nassif, G Ghazeeri… - PLoS …, 2015 - journals.plos.org
Objective To evaluate the effect of preoperative anaemia and blood transfusion on 30-day
postoperative morbidity and mortality in patients undergoing gynecological surgery. Study …

Role of transforming growth factor β in uterine fibroid biology

M Ciebiera, M Włodarczyk, M Wrzosek… - International Journal of …, 2017 - mdpi.com
Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth
muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones …

Uterine fibroids: clinical manifestations and contemporary management

L Doherty, L Mutlu, D Sinclair… - Reproductive …, 2014 - journals.sagepub.com
Uterine fibroids (leiomyomata) are extremely common lesions that are associated with
detrimental effects including infertility and abnormal uterine bleeding. Fibroids cause …

Selective progesterone receptor modulators (SPRMs) for uterine fibroids

A Murji, L Whitaker, TL Chow… - Cochrane Database of …, 2017 - cochranelibrary.com
Background Uterine fibroids are smooth muscle tumours arising from the uterus. These
tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk …

Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution

MB Moravek, SE Bulun - Current Opinion in Obstetrics and …, 2015 - journals.lww.com
The recent shift in focus from hormones to fibroid stem cells and genetic aberrations should
lead not only to a deeper understanding of the specific cause of fibroids, but also to the …