Molecular physiology of membrane guanylyl cyclase receptors
M Kuhn - Physiological reviews, 2016 - journals.physiology.org
cGMP controls many cellular functions ranging from growth, viability, and differentiation to
contractility, secretion, and ion transport. The mammalian genome encodes seven …
contractility, secretion, and ion transport. The mammalian genome encodes seven …
Cellular mechanisms of hereditary photoreceptor degeneration–Focus on cGMP
The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …
[HTML][HTML] Achromatopsia: genetics and gene therapy
S Michalakis, M Gerhardt, G Rudolph… - Molecular diagnosis & …, 2022 - Springer
Achromatopsia (ACHM), also known as rod monochromatism or total color blindness, is an
autosomal recessively inherited retinal disorder that affects the cones of the retina, the type …
autosomal recessively inherited retinal disorder that affects the cones of the retina, the type …
Why are rods more sensitive than cones?
NT Ingram, AP Sampath, GL Fain - The Journal of physiology, 2016 - Wiley Online Library
One hundred and fifty years ago Max Schultze first proposed the duplex theory of vision, that
vertebrate eyes have two types of photoreceptor cells with differing sensitivity: rods for dim …
vertebrate eyes have two types of photoreceptor cells with differing sensitivity: rods for dim …
Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration
E Vighi, D Trifunović, P Veiga-Crespo… - Proceedings of the …, 2018 - National Acad Sciences
Inherited retinal degeneration (RD) is a devastating and currently untreatable
neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The …
neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The …
Outer retinal tubulation in advanced age-related macular degeneration: optical coherence tomographic findings correspond to histology
Purpose: To compare optical coherence tomography (OCT) and histology of outer retinal
tubulation (ORT) secondary to advanced age-related macular degeneration in patients and …
tubulation (ORT) secondary to advanced age-related macular degeneration in patients and …
[HTML][HTML] The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development
The second messengers, cGMP and Ca 2+, have both been implicated in retinal
degeneration; however, it is still unclear which of the two is most relevant for photoreceptor …
degeneration; however, it is still unclear which of the two is most relevant for photoreceptor …
Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors
Calcium plays important roles in the function and survival of rod and cone photoreceptor
cells. Rapid regulation of calcium in the outer segments of photoreceptors is required for the …
cells. Rapid regulation of calcium in the outer segments of photoreceptors is required for the …
[HTML][HTML] Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration
A Roy, A Tolone, R Hilhorst, J Groten, T Tomar… - Cell Death …, 2022 - nature.com
Inherited retinal diseases (IRDs) are a group of neurodegenerative disorders that lead to
photoreceptor cell death and eventually blindness. IRDs are characterised by a high genetic …
photoreceptor cell death and eventually blindness. IRDs are characterised by a high genetic …
[PDF][PDF] Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations
A first-in-human clinical trial of gene therapy in Leber congenital amaurosis due to mutations
in the GUCY2D gene is underway, and early results are summarized. A recombinant adeno …
in the GUCY2D gene is underway, and early results are summarized. A recombinant adeno …