Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Importance Vascular risk factors have been associated with cognitive decline. Midlife
exposure to these factors may be most important in conferring late-life risk of cognitive …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

Hypertension is a highly prevalent condition which has been established as a risk factor for
cardiovascular and cerebrovascular disease. Although the understanding of the relationship …

The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Two decades of epidemiological research shows that silent cerebrovascular disease is
common and is associated with future risk for stroke and dementia. It is the most common …

Importance Hypertension is a treatable potential cause of cognitive decline and dementia,
but its greatest influence on cognition may occur in middle age. Objective To evaluate the …