Inflammatory and microbiota-related regulation of the intestinal epithelial barrier

G Barbara, MR Barbaro, D Fuschi, M Palombo… - Frontiers in …, 2021 - frontiersin.org
The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

Implication of intestinal barrier dysfunction in gut dysbiosis and diseases

C Stolfi, C Maresca, G Monteleone, F Laudisi - Biomedicines, 2022 - mdpi.com
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

DH Vasant, PA Paine, CJ Black, LA Houghton… - Gut, 2021 - gut.bmj.com
Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders
seen by clinicians in both primary and secondary care. Since publication of the last British …

Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice

G De Palma, MDJ Lynch, J Lu, VT Dang… - Science translational …, 2017 - science.org
Irritable bowel syndrome (IBS) is a common disorder characterized by altered gut function
and often is accompanied by comorbid anxiety. Although changes in the gut microbiota have …

Cell–cell junctions organize structural and signaling networks

MA Garcia, WJ Nelson… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

N Hanning, AL Edwinson, H Ceuleers… - Therapeutic …, 2021 - journals.sagepub.com
Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous
disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes …

The role of mast cells in functional GI disorders

MM Wouters, M Vicario, J Santos - Gut, 2016 - gut.bmj.com
Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints
arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity …

Intestinal inflammation and mucosal barrier function

F Sánchez de Medina, I Romero-Calvo… - Inflammatory bowel …, 2014 - academic.oup.com
Intestinal mucosal barrier function is the capacity of the intestine to provide adequate
containment of luminal microorganisms and molecules while preserving the ability to absorb …

[HTML][HTML] Irritable bowel syndrome: a microbiome-gut-brain axis disorder?

PJ Kennedy, JF Cryan, TG Dinan… - World journal of …, 2014 - ncbi.nlm.nih.gov
Irritable bowel syndrome (IBS) is an extremely prevalent but poorly understood
gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help …

A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function

MI Vazquez–Roque, M Camilleri, T Smyrk, JA Murray… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Patients with diarrhea-predominant irritable bowel syndrome (IBS-
D) could benefit from a gluten-free diet (GFD). METHODS: We performed a randomized …