Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

NADPH oxidases (NOX) are enzyme complexes that have received much attention as key
molecules in the development of vascular dysfunction. NOX have the primary function of …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

People with type 2 diabetes mellitus (T2DM) have a 25-fold higher risk of limb loss than non-
diabetics due in large part to impaired wound healing. Here, we show that the impaired …

Oxidative stress-associated endothelial dysfunction is a key pathogenic factor underlying the
microvascular complications of metabolic disease. NADPH oxidase (Nox) is a major source …

Diabetic retinopathy (DR) manifests as a complicated and blinding complication in diabetes
mellitus. First-line treatments for advanced DR have shown ocular side-effects in some …

Insulin plays an indispensable role in the management of hyperglycaemia that arises in a
variety of settings, including Type I and II diabetes, gestational diabetes, as well as is in …

Abstract Significance: Highly prevalent in Western cultures, obesity, metabolic syndrome,
and diabetes increase the risk of cardiovascular morbidity and mortality and cost health care …

Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple
experimental and clinical studies have shown increased oxidative stress and inflammation …

Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to
pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 …