[HTML][HTML] Current trends in pharmaceutical treatment of dry eye disease: A review

HB Mohamed, BN Abd El-Hamid, D Fathalla… - European Journal of …, 2022 - Elsevier
Dry eye disease (DED), keratoconjunctivitis sicca or dysfunctional tear syndrome, is the most
prevalent ophthalmic disease which affects a substantial segment of people worldwide with …

[HTML][HTML] Novel drug delivery systems for the management of dry eye

N Nagai, H Otake - Advanced drug delivery reviews, 2022 - Elsevier
Dry eye disease (DED) is a frequently observed eye complaint, which has recently attracted
considerable research interest. Conventional therapy for DED involves the use of artificial …

[HTML][HTML] Formulation considerations for the management of dry eye disease

P Agarwal, JP Craig, ID Rupenthal - Pharmaceutics, 2021 - mdpi.com
Dry eye disease (DED) is one of the most common ocular surface disorders characterised by
a deficiency in quality and/or quantity of the tear fluid. Due to its multifactorial nature …

[HTML][HTML] Cyclodextrin stabilized freeze-dried silica/chitosan nanoparticles for improved terconazole ocular bioavailability

N Zaghloul, NM El Hoffy, AA Mahmoud, NA Elkasabgy - Pharmaceutics, 2022 - mdpi.com
This research assesses the beneficial effects of loading terconazole, a poorly water-soluble
antifungal drug in silica/chitosan nanoparticles (SCNs) for ocular delivery. Nanoparticles …

[HTML][HTML] Novel eye drop delivery systems: advance on formulation design strategies targeting anterior and posterior segments of the eye

Y Wang, C Wang - Pharmaceutics, 2022 - mdpi.com
Eye drops are the most common and convenient route of topical administration and the first
choice of treatment for many ocular diseases. However, the ocular bioavailability of …

[HTML][HTML] Development and characterization of a tacrolimus/hydroxypropyl-β-cyclodextrin eye drop

X García-Otero, V Díaz-Tomé, R Varela-Fernández… - Pharmaceutics, 2021 - mdpi.com
Uveitis is a vision inflammatory disorder with a high prevalence in developing countries.
Currently, marketed treatments remain limited and reformulation is usually performed to …

Drug-like properties and topical delivery of rapalogs and tacrolimus in ophthalmology

HH Sigurdsson, P Jansook, T Loftsson - Journal of Drug Delivery Science …, 2024 - Elsevier
Rapalogs, including sirolimus and everolimus, as well as tacrolimus, are macrolide
immunosuppressants that have emerged as promising therapeutic agents in ophthalmology …

Research progress of ophthalmic preparations of immunosuppressants

Y Liu, H Xu, N Yan, Z Tang, Q Wang - Drug Delivery, 2023 - Taylor & Francis
Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants
are drugs that can inhibit the body's immune response. Considering drug side effects such …

Cyclodextrin‐based nanosponges as promising carriers for active pharmaceutical ingredient

S Jawaharlal, S Subramanian… - … of Biochemical and …, 2024 - Wiley Online Library
Effective drug distribution at the intended or particular location is a critical issue that
researchers are now dealing. Nanosponges have significantly increased in importance in …

Difluprednate-hydroxypropyl-β-cyclodextrin-based ophthalmic solution for improved delivery in a porcine eye model

H Shelley, M Annaji, FT Smith… - Journal of Ocular …, 2022 - liebertpub.com
Purpose: Difluprednate (DFP) is an approved corticosteroid, available as an ophthalmic
emulsion (Durezol®), used to treat pain and inflammation of the eye following ocular …