Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with developing methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …

[HTML][HTML] In-cell NMR: Why and how?

FX Theillet, E Luchinat - Progress in Nuclear Magnetic Resonance …, 2022 - Elsevier
NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

[HTML][HTML] Triple-negative breast cancer: present challenges and new perspectives

F Podo, LMC Buydens, H Degani, R Hilhorst, E Klipp… - Molecular …, 2010 - Elsevier
Triple-negative breast cancers (TNBC), characterized by absence of estrogen receptor (ER),
progesterone receptor (PR) and lack of overexpression of human epidermal growth factor …

Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine

J Carrola, CM Rocha, AS Barros, AM Gil… - Journal of proteome …, 2011 - ACS Publications
In this study, 1H NMR-based metabonomics has been applied, for the first time to our
knowledge, to investigate lung cancer metabolic signatures in urine, aiming at assessing the …

Metabolomics as a tool for the comprehensive understanding of fermented and functional foods with lactic acid bacteria

F Mozzi, ME Ortiz, J Bleckwedel, L De Vuyst… - Food Research …, 2013 - Elsevier
Metabolomics, also called metabonomics or metabolic profiling, deals with the simultaneous
determination and quantitative analysis of intracellular metabolites or low-molecular-mass …

Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of blood plasma

CM Rocha, J Carrola, AS Barros, AM Gil… - Journal of proteome …, 2011 - ACS Publications
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients
and healthy controls were investigated through NMR-based metabonomics, to assess the …

[HTML][HTML] Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide

MH Kulke, T O'Dorisio, A Phan… - Endocrine-Related …, 2014 - erc.bioscientifica.com
In this study, we i) assessed the metabolic profile of the normal adrenal cortex and medulla
of adult human subjects by means of 1 H-high-resolution magic-angle spinning nuclear …

A serum nuclear magnetic resonance-based metabolomic signature of advanced metastatic human breast cancer

E Jobard, C Pontoizeau, BJ Blaise, T Bachelot… - Cancer letters, 2014 - Elsevier
Breast cancer (BC) displays a high heterogeneity from histology to prognosis, metastatic
evolution and treatment responses. We report here a 1 H NMR-based metabolic …

Metabolic Profiling of Human Lung Cancer Tissue by 1H High Resolution Magic Angle Spinning (HRMAS) NMR Spectroscopy

CM Rocha, AS Barros, AM Gil… - Journal of proteome …, 2010 - ACS Publications
This work aims at characterizing the metabolic profile of human lung cancer, to gain new
insights into tumor metabolism and to identify possible biomarkers with potential diagnostic …