[HTML][HTML] Integrated physiology and systems biology of PPARα
S Kersten - Molecular metabolism, 2014 - Elsevier
Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …
factor that plays a major role in metabolic regulation. This review addresses the functional …
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
AC Calkin, P Tontonoz - Nature reviews Molecular cell biology, 2012 - nature.com
Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance
between the production and clearance of Aβ (amyloid beta) is considered to be actively …
between the production and clearance of Aβ (amyloid beta) is considered to be actively …
Nutrient-sensing nuclear receptors coordinate autophagy
Autophagy is an evolutionarily conserved catabolic process that recycles nutrients upon
starvation and maintains cellular energy homeostasis,,. Its acute regulation by nutrient …
starvation and maintains cellular energy homeostasis,,. Its acute regulation by nutrient …
Peroxisome proliferator‐activated receptor alpha target genes
The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …
transcription factor involved in the regulation of a variety of processes, ranging from …
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
Fat and beyond: the diverse biology of PPARγ
P Tontonoz, BM Spiegelman - Annu. Rev. Biochem., 2008 - annualreviews.org
The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …
role in the control of gene expression linked to a variety of physiological processes. PPARγ …
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Peroxisome proliferator-activated receptor 72 (PPARy2) is an adipocyte-specific nuclear
hormone receptor that has recently been identified as a key regulator of two fat cell …
hormone receptor that has recently been identified as a key regulator of two fat cell …
Peroxisome proliferator-activated receptors: nuclear control of metabolism
B Desvergne, W Wahli - Endocrine reviews, 1999 - academic.oup.com
B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …
The RXR heterodimers and orphan receptors
DJ Mangelsdorf, RM Evans - Cell, 1995 - Elsevier
The nuclear receptor superfamily is comprised of over 150 different proteins that have
evolved to mediate a complex array of extracellular signals into transcriptional responses …
evolved to mediate a complex array of extracellular signals into transcriptional responses …