The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation,
histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide …

Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-
essential amino acid involved in cell proliferation. Serine metabolism, especially the de novo …

Cancer cells modulate their metabolic activities to adapt to their growth and proliferation.
Despite advances in breast cancer biology having led to the widespread use of molecular …

Lung adenocarcinoma (LUAD) is the most common type of lung cancer, accounting for
approximately 85% of pulmonary malignancies. Emerging evidence has demonstrated that …

Despite significant advances in the treatment of colorectal cancer (CRC), identification of
novel targets and treatment options are imperative for improving its prognosis and survival …

Abstract Objective Serine hydroxymethyltransferase 2 (SHMT2) is the first rate-limiting
enzyme for serine/glycine biosynthesis and one carbon metabolism. Here, we explore the …

Cancer cells selectively take up exogenous serine or synthesize serine via the serine
synthesis pathway for conversion into intracellular glycine and one‐carbon units for …

Cancer cells alter their metabolism and epigenetics to support cancer progression.
However, very few modulators connecting metabolism and epigenetics have been …

Abstract Background One‐carbon (1C) metabolism is a metabolic network that plays
essential roles in biological reactions. In 1C metabolism, a series of nutrients are used to …

摘要背景与目的: 胰腺癌是预后极差的恶性肿瘤, 其5 年生存率约为11.5%, 有将近半数的患者在
初诊时已出现远处转移, 而肝转移则占到其中的37.0%~ 41.9%. 探索新的胰腺癌肝转移的生物 …