[HTML][HTML] Recent insights into zebrafish cardiac regeneration

A Sanz-Morejon, N Mercader - Current opinion in genetics & development, 2020 - Elsevier
In humans, myocardial infarction results in ventricular remodeling, progressing ultimately to
cardiac failure, one of the leading causes of death worldwide. In contrast to the adult …

Comparative study in zebrafish and medaka unravels the mechanisms of tissue regeneration

K Chowdhury, S Lin, SL Lai - Frontiers in Ecology and Evolution, 2022 - frontiersin.org
Tissue regeneration has been in the spotlight of research for its fascinating nature and
potential applications in human diseases. The trait of regenerative capacity occurs diversely …

Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

MA Botos, P Arora, P Chouvardas, N Mercader - Scientific Reports, 2023 - nature.com
Zebrafish have the capacity to fully regenerate the heart after an injury, which lies in sharp
contrast to the irreversible loss of cardiomyocytes after a myocardial infarction in humans …

[HTML][HTML] Integrated K+ channel and K+ Cl-cotransporter functions are required for the coordination of size and proportion during development

JS Lanni, D Peal, L Ekstrom, H Chen, C Stanclift… - Developmental …, 2019 - Elsevier
The coordination of growth during development establishes proportionality within and
among the different anatomic structures of organisms. Innate memory of this proportionality …

Midkine-a is required for cell cycle progression of Müller glia during neuronal regeneration in the vertebrate retina

M Nagashima, TS D'Cruz, AE Danku… - Journal of …, 2020 - Soc Neuroscience
In the retina of zebrafish, Müller glia have the ability to reprogram into stem cells capable of
regenerating all classes of retinal neurons and restoring visual function. Understanding the …

Alpha-1 adrenergic signaling drives cardiac regeneration via extracellular matrix remodeling transcriptional program in zebrafish macrophages

O Apaydin, A Altaikyzy, A Filosa, S Sawamiphak - Developmental Cell, 2023 - cell.com
The autonomic nervous system plays a pivotal role in cardiac repair. Here, we describe the
mechanistic underpinning of adrenergic signaling in fibrotic and regenerative response of …

Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration

Y Cao, Y Xia, JJ Balowski, J Ou, L Song, A Safi… - …, 2022 - journals.biologists.com
The epicardium is a mesothelial tissue layer that envelops the heart. Cardiac injury activates
dynamic gene expression programs in epicardial tissue, which in zebrafish enables …

Inflammation is a critical factor for successful regeneration of the adult zebrafish retina in response to diffuse light lesion

O Bludau, A Weber, V Bosak, V Kuscha… - Frontiers in Cell and …, 2024 - frontiersin.org
Inflammation can lead to persistent and irreversible loss of retinal neurons and
photoreceptors in mammalian vertebrates. In contrast, in the adult zebrafish brain, acute …

Towards comparative analyses of salamander limb regeneration

VB Dwaraka, SR Voss - Journal of Experimental Zoology Part B …, 2021 - Wiley Online Library
Among tetrapods, only salamanders can regenerate their limbs and tails throughout life. This
amazing regenerative ability has attracted the attention of scientists for hundreds of years …

Glucocorticoid treatment leads to aberrant ion and macromolecular transport in regenerating zebrafish fins

JR Schmidt, K Geurtzen, M Von Bergen… - Frontiers in …, 2019 - frontiersin.org
Long-term glucocorticoid administration in patients undergoing immunosuppressive and anti-
inflammatory treatment is accompanied by impaired bone formation and increased fracture …