Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

Characterizing metabolism in cancer is crucial for understanding tumor biology and for
developing potential therapies. Although most metabolic investigations analyze averaged …

Increasing evidence suggests that the spatial distribution of biomolecules within cells is a
critical component in deciphering single-cell molecular heterogeneity. State-of-the-art single …

Matrix assisted laser desorption/ionization imaging has greatly improved our understanding
of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here …

A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Since our last comprehensive review on multi‐dimensional mass spectrometry‐based
shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the …

▪ Abstract In this review, recent advances in DNA microarray technology and their
applications are examined. The many varieties of DNA microarray or DNA chip devices and …

We have employed matrix deposition by sublimation for protein image analysis on tissue
sections using a hydration/recrystallization process that produces high-quality MALDI mass …

Live single-cell mass spectrometry (live MS) provides a mass spectrum that shows
thousands of metabolite peaks from a single live plant cell within minutes. By using an …

Practical guidelines for the preparation of tissue sections for direct analysis by matrix‐
assisted laser desorption/ionization (MALDI) mass spectrometry are presented. Techniques …