Perinatal asphyxia-induced brain injury may present as hypoxic-ischemic encephalopathy in
the neonatal period, and disability including cerebral palsy in the long term. The brain injury …

Neonatal hypoxia-ischemia and resulting encephalopathies are of significant concern.
Intrapartum asphyxia is a leading cause of neonatal death globally. Among surviving infants …

Therapeutic hypothermia (HT) is standard care for moderate and severe neonatal hypoxic-
ischaemic encephalopathy (HIE), the leading cause of permanent brain injury in term …

Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI)
encephalopathy. However, the efficacy of HT in preclinical models, such as the Vannucci …

Background: Microglia are key mediators of inflammation during perinatal brain injury. As
shown experimentally after inflammation-sensitized hypoxic ischemic (HI) brain injury …

Background: Perinatal asphyxia, leading to neonatal encephalopathy, is one of the leading
causes for child mortality and long-term morbidities. Neonatal encephalopathy rates are …

Neonatal hypoxic–ischaemic brain damage is a leading cause of child mortality and
morbidity, including cerebral palsy, epilepsy, and cognitive disabilities. The majority of …

Hypoxic‐ischemic encephalopathy (HIE) mainly affects preterm and term newborns, leading
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …

Therapeutic hypothermia (TH) is now well established to improve intact survival after
neonatal encephalopathy (NE). However, many questions could not be addressed by the …

Background Increased systemic and tissue levels of interleukin (IL)-1β are associated with
greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis …