Human African trypanosomiasis (HAT), or sleeping sickness, is caused by Trypanosoma
brucei gambiense, which is a chronic form of the disease present in western and central …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Sexual reproduction and clonality in eukaryotes are mostly seen as exclusive, the latter
being rather exceptional. This view might be biased by focusing almost exclusively on …

Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other
mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single …

Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental
evolutionary transitions in the history of life on earth. This event, which is estimated to have …

Salivarian trypanosomes are single cell extracellular parasites that cause infections in a
wide range of hosts. Most pathogenic infections worldwide are caused by one of four major …

Sexual reproduction is a nearly universal feature of eukaryotic organisms. Given its ubiquity
and shared core features, sex is thought to have arisen once in the last common ancestor to …

Although asexual reproduction via clonal propagation has been proposed as the principal
reproductive mechanism across parasitic protozoa of the Leishmania genus, sexual …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

The life cycle of the Leishmania parasite in the sand fly vector involves differentiation into
several distinctive forms, each thought to represent an adaptation to specific …