Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Multidrug resistance is quite common among non-fermenting Gram-negative rods, in
particular among clinically relevant species including Pseudomonas aeruginosa and …

ABSTRACT Introduction: Enterobacteriaceae, Pseudomonas spp., and Acinetobacter spp.
infections are major causes of morbidity and mortality, especially due to the emergence and …

Background Carbapenemase production is a global public health threat. Antimicrobial
resistance (AMR) data analysis is critical to public health policy. Here we analyzed …

Acinetobacter baumannii is widely recognized as an important pathogen associated with
nosocomial infections. The treatment of these infections is often difficult due to the …

Carbapenem resistance in gram-negative bacteria by production of carbapenemases is one
of the most challenging issues regarding healthcare worldwide. We review the epidemiology …

Horizontal gene transfer (HGT) is a driving force to the evolution of bacteria. The fast
emergence of antimicrobial resistance reflects the ability of genetic adaptation of pathogens …

In Enterobacteriaceae, the bla NDM genes have been found in many different genetic
contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In …

Antimicrobial resistance (AMR) is a major public health threat of global proportions, which
has the potential to lead to approximately ten million deaths per year by 2050. Pressured by …

The production of new pyrazole amide derivatives (6a-h) and their potential against New
Delhi metallo-β-lactamase-1 (NDM-1) producing bacteria was described in the present …