Adenocarcinoma has become the most prevalent lung cancer sub-type and its frequency is
increasing. The earliest stages in the development of lung adenocarcinomas are visible …

Abstract The 2021 WHO Classification of Thoracic Tumours was published earlier this year,
with classification of lung tumors being one of the chapters. The principles remain those of …

The cell ecology and spatial niche implicated in the dynamic and sequential process of lung
adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive …

Simple Summary Immune escape mechanisms have been identified in every step of lung
tumorigenesis. A heterogeneous ensemble of immune evasion processes shapes the …

Metabolic reprogramming evolves during cancer initiation and progression. However,
thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma …

APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when
APOBEC3 expression is induced during cancer development remains to be defined. Here …

Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is
responsible for the majority of cancer-related deaths worldwide. The management of …

Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical
adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally …

The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung
adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of …

Simple Summary Tissue biopsy is essential for diagnosis and characterization of a tumor.
Recently circulating tumor cells and other tumor-derived nucleic acid can be detected from …