Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
maintaining multiorgan health and homeostasis. Endothelial functions in health include …
Vascular inflammation and oxidative stress: major triggers for cardiovascular disease
S Steven, K Frenis, M Oelze, S Kalinovic… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
Sources of vascular nitric oxide and reactive oxygen species and their regulation
J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
[HTML][HTML] ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
Reactive oxygen species and redox signaling in chronic kidney disease
MV Irazabal, VE Torres - Cells, 2020 - mdpi.com
Chronic kidney disease (CKD) remains a worldwide public health problem associated with
serious complications and increased mortality rates. Accumulating evidence indicates that …
serious complications and increased mortality rates. Accumulating evidence indicates that …
[HTML][HTML] Reperfusion injury and reactive oxygen species: The evolution of a concept
DN Granger, PR Kvietys - Redox biology, 2015 - Elsevier
Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …
deprived and oxygen-starved organs following the restoration of blood flow and tissue …
Antioxidant effects of resveratrol in the cardiovascular system
The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …
substantially to the health benefits of this compound. Resveratrol has been shown to be a …
[HTML][HTML] Biochemical basis and metabolic interplay of redox regulation
L Zhang, X Wang, R Cueto, C Effi, Y Zhang, H Tan… - Redox biology, 2019 - Elsevier
Accumulated evidence strongly indicates that oxidative stress, characterized by an
imbalance between reactive oxygen species (ROS) production and antioxidants in favor of …
imbalance between reactive oxygen species (ROS) production and antioxidants in favor of …
Targeting vascular (endothelial) dysfunction
A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …
years, with hypertension a significant risk factor for all causes of death. The endothelium that …