Applications of isosteres of piperazine in the design of biologically active compounds: part 1
NA Meanwell, O Loiseleur - Journal of Agricultural and Food …, 2022 - ACS Publications
Piperazine and homopiperazine are well-studied heterocycles in drug design that have
found gainful application as scaffolds and terminal elements and for enhancing the aqueous …
found gainful application as scaffolds and terminal elements and for enhancing the aqueous …
Aminative Suzuki–Miyaura coupling
P Onnuch, K Ramagonolla, RY Liu - Science, 2024 - science.org
The Suzuki–Miyaura and Buchwald–Hartwig coupling reactions are widely used to form
carbon-carbon (C–C) and carbon-nitrogen (C–N) bonds, respectively. We report the …
carbon-carbon (C–C) and carbon-nitrogen (C–N) bonds, respectively. We report the …
Development and Therapeutic Perspectives of CXCR4 Antagonists for Disease Therapy
J Yang, E Tian, L Chen, Z Liu, Y Ren, W Mao… - European Journal of …, 2024 - Elsevier
Abstract Chemokine receptor 4 (CXCR4) is a subtype receptor protein of the GPCR family
with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is …
with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is …
Scale-Up Preparation of Best-In-Class Orally Bioavailable CXCR4 Antagonist EMU-116 in an Academic Setting
CXCR4 is a seven-transmembrane chemokine receptor that is intimately involved in stem
cell niche maintenance and immune cell trafficking. Among several other pathophysiological …
cell niche maintenance and immune cell trafficking. Among several other pathophysiological …
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles
E Jecs, YA Tahirovic, RJ Wilson, EJ Miller… - Journal of Medicinal …, 2022 - ACS Publications
Our first-generation CXCR4 antagonist TIQ15 was rationally modified to improve drug-like
properties. Introducing a nitrogen atom into the aromatic portion of the …
properties. Introducing a nitrogen atom into the aromatic portion of the …