The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

HuR as a molecular target for cancer therapeutics and immune-related disorders

M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

Regulatory mechanisms of the early phase of white adipocyte differentiation: An overview

M Audano, S Pedretti, D Caruso, M Crestani… - Cellular and molecular …, 2022 - Springer
The adipose organ comprises two main fat depots termed white and brown adipose tissues.
Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor …

HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation

Y Li, W Sun, J Li, R Du, W Xing, X Yuan, G Zhong… - Bone Research, 2023 - nature.com
Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast
function play critical roles in bone formation, which is a highly regulated process. Long …

Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression

YC Chang, MH Chan, YF Yang, CH Li, M Hsiao - Cancer Letters, 2023 - Elsevier
The glucose transporter family (GLUT) consists of fourteen members. It is responsible for
glucose homeostasis and glucose transport from the extracellular space to the cell …

[HTML][HTML] Development and validation of a RNA binding protein-associated prognostic model for lung adenocarcinoma

W Li, LN Gao, PP Song, CG You - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
RNA binding proteins (RBPs) dysregulation have been reported in various malignant tumors
and associated with the occurrence and development of cancer. However, the role of RBPs …

RNA binding proteins in senescence: a potential common linker for age-related diseases?

A Varesi, LIM Campagnoli, A Barbieri, L Rossi… - Ageing Research …, 2023 - Elsevier
Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

RNA-binding proteins in the regulation of adipogenesis and adipose function

P Zhang, W Wu, C Ma, C Du, Y Huang, H Xu, C Li… - Cells, 2022 - mdpi.com
The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …

Caffeic and chlorogenic acids synergistically activate browning program in human adipocytes: Implications of AMPK-and PPAR-mediated pathways

LV Vasileva, MS Savova, KM Amirova… - International Journal of …, 2020 - mdpi.com
Caffeic acid (CA) and chlorogenic acid (CGA) are phenolic compounds claimed to be
responsible for the metabolic effects of coffee and tea consumption. Along with their …

Identification of the functions and prognostic values of RNA binding proteins in bladder cancer

Y Wu, Z Liu, X Wei, H Feng, B Hu, B Liu, Y Luan… - Frontiers in …, 2021 - frontiersin.org
Post-transcriptional regulation plays a leading role in gene regulation and RNA binding
proteins (RBPs) are the most important posttranscriptional regulatory protein. RBPs had …