ABSTRACT Introduction The concept of Digital Twins (DTs) translated to drug development
and clinical trials describes virtual representations of systems of various complexities …

The creation and application of data in biomedicine and healthcare often face privacy
constraints, bias, distributional shifts, underrepresentation of certain groups and data …

The treatment landscape for multiple myeloma (MM) has experienced substantial progress
over the last decade. Despite the efficacy of new substances, patient responses tend to still …

Background Mild cognitive impairment (MCI) is the early stage of AD, and about 10–12% of
MCI patients will progress to AD every year. At present, there are no effective markers for the …

Objectives The use of synthetic data to supplement clinical trial placebo groups or for trial
planning is rapidly gaining interest. However, there is not yet an established framework for …

Modern drug development is increasingly complex and requires strategic application of
novel quantitative disciplines such as pharmacometrics (PMx) and machine learning (ML) …

While some model‐informed drug development frameworks are well recognized as enabling
clinical trials, the value of disease progression modeling (DPM) in impacting medical …

Abstract The use of Sequential Multiple Assignment Randomized Trial (SMART) design in
digital precision health studies is gaining popularity due to its flexibility and efficiency …