Cancer progresses through a series of histopathological stages. Progression is thought to
be driven by the accumulation of genetic alterations and consequently gene expression …

The field of cytogenetics has focused on studying the number, structure, function and origin
of chromosomal abnormalities and the evolution of chromosomes. The development of …

Small cell lung cancer (SCLC) is the lung neoplasia with the poorest prognosis, due to its
high metastatic potential and chemoresistance upon relapse. Using the previously …

Substantial evidence suggests that chromosomal abnormalities contribute to the risk of
autism. The duplication of human chromosome 15q11-13 is known to be the most frequent …

The mammalian genome contains several hundred microRNAs that regulate gene
expression through modulation of target mRNAs. Here, we report a fragile chromosomal …

Women carrying germ-line mutations in BRCA1 are strongly predisposed to developing
breast cancers with characteristic features also observed in sporadic basal-like breast …

Nucleophosmin (also known as NPM, B23, NO38) is a nucleolar protein directly implicated
in cancer pathogenesis, as the NPM1 gene is found mutated and rearranged in a number of …

Purpose: To assess efficacy of the novel, selective poly (ADP-ribose) polymerase-1 (PARP-
1) inhibitor AZD2281 against newly established BRCA2-deficient mouse mammary tumor …

Multiple displacement amplification (MDA) is a technique used in the amplification of very
low amounts of DNA and reported to yield large quantities of high-quality DNA. We used …

Background The domestic pig is being increasingly exploited as a system for modeling
human disease. It also has substantial economic importance for meat-based protein …