The plasma coagulation system in mammalian blood consists of a cascade of enzyme
activation events in which serine proteases activate the proteins (proenzymes and …

Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Coagulation factor XI is activated in vitro by factor XIIa in the presence of high molecular
weight kininogen (HMWK) and a negatively charged surface. Factor XII deficiency is not …

The pre-eminent reference on coagulation disorders is now in its thoroughly updated Fifth
Edition. Written by more than 160 of the world's foremost authorities, this encyclopedic …

Historical Background It has been recognized for almost 100 years that a number of
bacterial products have the capacity to exert profound effects on humans and other animals …

Bradykinin is formed by the interaction of factor XII, prekallikrein, and high-molecular-weight
kininogen on negatively charged inorganic surfaces (silicates, urate, and pyrophosphate) or …

Prekallikrein and high-molecular-weight kininogen were found associated in normal human
plasma at a molecular weight of 285,000 as assessed by gel filtration on Sephadex G-200 …

MATERIALS AND METHODS All chemicals obtained from commercial sources were the
best grade available. Human Factor XII (80 clotting units/mg) was purified on DEAE …

The general hypothesis for the biological function of beta 2-glycoprotein I is that it
neutralizes all negatively charged macromolecules that might enter the bloodstream and …

The mechanism by which negatively charged substances such as celite, kaolin, or ellagic
acid contribute to the surface-dependent activation of Hageman factor (Factor XII) was …