Is there a role for dacomitinib, a second-generation irreversible inhibitor of the epidermal-growth factor receptor tyrosine kinase, in advanced non-small cell lung …
C Bergonzini, A Leonetti, M Tiseo… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Non-small cell lung cancer (NSCLC) is a highly lethal disease. During the past
20 years, the epidermal growth factor receptor (EGFR) has been a relevant target for …
20 years, the epidermal growth factor receptor (EGFR) has been a relevant target for …
HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs
Background Patients with non‐small cell lung cancer (NSCLC) harboring activating EGFR
mutations are sensitive to epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR …
mutations are sensitive to epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR …
[PDF][PDF] Different EGF-induced receptor dimer conformations for signaling and internalization
J Haubrich, JM Zwier, F Charrier-Savournin, L Prézeau… - 2024 - repository.ubn.ru.nl
The structural basis of the activation and internalization of EGF receptors (EGFR) is still a
matter of debate despite the importance of this target in cancer treatment. Whether agonists …
matter of debate despite the importance of this target in cancer treatment. Whether agonists …
Different conformations of EGF-induced receptor dimers involved in signaling and internalization
J Haubrich, JM Zwier, F Charrier-Savournin, L Prézeau… - bioRxiv, 2022 - biorxiv.org
The structural basis of the activation of EGF receptors (EGFR) is still a matter of debate
despite the importance of this target in cancer treatment. Whether agonists induce dimer …
despite the importance of this target in cancer treatment. Whether agonists induce dimer …
Conformational dynamics and pharmacology in transmembrane dimeric receptors
J Haubrich - 2021 - theses.hal.science
Transmembrane receptors are proteins that translate extracellular information into
intracellular signals. These proteins are categorised based on the way they transduce …
intracellular signals. These proteins are categorised based on the way they transduce …
[PDF][PDF] An HSP90 inhibitor overcomes EGFR amplification-induced resistance to third-generation EGFR-TKIs
渡辺翔， ワタナベショウ - Thoracic Cancer, 2021 - ir.jikei.ac.jp
Background: Patients with non-small cell lung cancer (NSCLC) harboring activating EGFR
mutations are sensitive to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR …
mutations are sensitive to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR …