Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, and approaches to clinical care and rehabilitation

SJ Singh, MM Baldwin, E Daynes, RA Evans… - The Lancet …, 2023 - thelancet.com
Although the exact prevalence of post-COVID-19 condition (also known as long COVID) is
unknown, more than a third of patients with COVID-19 develop symptoms that persist for …

Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases

M Ezzo, B Hinz - Pharmacology & therapeutics, 2023 - Elsevier
The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

3-year outcomes of discharged survivors of COVID-19 following the SARS-CoV-2 omicron (B. 1.1. 529) wave in 2022 in China: a longitudinal cohort study

H Zhang, C Huang, X Gu, Y Wang, X Li… - The Lancet …, 2024 - thelancet.com
Background There is a paucity of data on the natural trajectory of outcomes in survivors of
COVID-19 beyond 2 years after symptom onset, and no evidence exists on the effect of re …

[HTML][HTML] Survival≠ recovery: a narrative review of post-intensive care syndrome

E Schwitzer, KS Jensen, L Brinkman, L DeFrancia… - CHEST Critical …, 2023 - Elsevier
Surviving critical illness does not always equate to recovery, with its aftermath frequently
complicated by post-intensive care syndrome (PICS). This syndrome consists of a collection …

Interstitial Lung Disease: A Review

TM Maher - JAMA, 2024 - jamanetwork.com
Importance Interstitial lung disease (ILD) consists of a group of pulmonary disorders
characterized by inflammation and/or fibrosis of the lung parenchyma associated with …

Prevalence, risk factors, and outcomes of adult interstitial lung abnormalities: a systematic review and meta-analysis

A Grant-Orser, B Min, S Elmrayed… - American Journal of …, 2023 - atsjournals.org
Rationale: Incidental parenchymal abnormalities detected on chest computed tomography
scans are termed interstitial lung abnormalities (ILAs). ILAs may represent early interstitial …

COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes

C Wang, MS Khatun, Z Zhang, MJ Allen… - Communications …, 2023 - nature.com
SARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying
mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 …

Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection: a prospective nationwide cohort study in the United States

A Adegunsoye, R Baccile, TJ Best, V Zaksas… - The Lancet Regional …, 2023 - thelancet.com
Background Pulmonary fibrosis is characterized by lung parenchymal destruction and can
increase morbidity and mortality. Pulmonary fibrosis commonly occurs following …

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

HJC McAuley, RA Evans, CE Bolton… - …, 2023 - thelancet.com
Background The scale of COVID-19 and its well documented long-term sequelae support a
need to understand long-term outcomes including frailty. Methods This prospective cohort …

Cluster analysis to identify long COVID phenotypes using 129Xe magnetic resonance imaging: a multicentre evaluation

RL Eddy, D Mummy, S Zhang, H Dai… - European …, 2024 - Eur Respiratory Soc
Background Long COVID impacts∼ 10% of people diagnosed with coronavirus disease
2019 (COVID-19), yet the pathophysiology driving ongoing symptoms is poorly understood …