Major depressive disorder (MDD) is common and moderately heritable. Recurrence and
early age at onset characterize cases with the greatest familial risk. Major depressive …

Schizophrenic and bipolar disorders are similar in several epidemiologic respects, including
age at onset, lifetime risk, course of illness, worldwide distribution, risk for suicide, gender …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to
siblings of probands. Replication has been inconsistent for reports of significant genetic …

We have conducted a genome screen of autism, by linkage analysis in an initial set of 90
multiplex sibships, with parents, containing 97 independent affected sib pairs (ASPs), with …

Several lines of evidence have implicated genetic factors in homosexuality. The most
compelling observation has been the report of genetic linkage of male homosexuality to …

A genome scan was previously performed and pointed to chromosome 6q21 as a candidate
region for autism. This region contains the glutamate receptor 6 (GluR6 or GRIK2) gene, a …

Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage.
The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD …

To provide a definitive linkage map for multiple sclerosis, we have genotyped the Illumina
BeadArray linkage mapping panel (version 4) in a data set of 730 multiplex families of …

This well-organized and clearly written text has a unique focus on methods of identifying the
joint effects of genes and environment on disease patterns. It follows the natural sequence of …