International union of basic and clinical pharmacology. CXII: adenosine receptors: a further update

AP IJzerman, KA Jacobson, CE Müller… - Pharmacological …, 2022 - ASPET
Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Regulation of microglial functions by purinergic mechanisms in the healthy and diseased CNS

P Illes, P Rubini, H Ulrich, Y Zhao, Y Tang - Cells, 2020 - mdpi.com
Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …

[HTML][HTML] Caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-κB and A2aR signaling in LPS-Induced THP-1 macrophages

W Zhao, L Ma, C Cai, X Gong - International journal of biological …, 2019 - ncbi.nlm.nih.gov
Excessive inflammation induced by various risk factors is associated with the development
of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a …

Neuroprotective strategies for retinal ganglion cell degeneration: current status and challenges ahead

R Boia, N Ruzafa, ID Aires, X Pereiro… - International journal of …, 2020 - mdpi.com
The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …

Purinergic signaling orchestrating neuron-glia communication

P Agostinho, D Madeira, L Dias, AP Simões… - Pharmacological …, 2020 - Elsevier
This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

More than meets the eye: The role of microglia in healthy and diseased retina

E Murenu, MJ Gerhardt, M Biel… - Frontiers in …, 2022 - frontiersin.org
Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …

Neurodegenerative diseases: Can caffeine be a powerful ally to weaken neuroinflammation?

M Ruggiero, R Calvello, C Porro, G Messina… - International Journal of …, 2022 - mdpi.com
In recent years, there has been considerable research showing that coffee consumption
seems to be beneficial to human health, as it contains a mixture of different bioactive …

CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling

F Meng, Z Guo, Y Hu, W Mai, Z Zhang, B Zhang, Q Ge… - Brain, 2019 - academic.oup.com
Ectonucleotidase-mediated ATP catabolism provides a powerful mechanism to control the
levels of extracellular adenosine. While increased adenosine A2A receptor (A2AR) …

[HTML][HTML] Porous poly (ε-caprolactone) implants: A novel strategy for efficient intraocular drug delivery

R Boia, PAN Dias, JM Martins… - Journal of Controlled …, 2019 - Elsevier
This work reports the development of porous poly (ε-caprolactone)(PCL)-based intraocular
implants, prepared by green supercritical carbon dioxide (scCO 2) foaming/mixing method …

Caffeine and modafinil ameliorate the neuroinflammation and anxious behavior in rats during sleep deprivation by inhibiting the microglia activation

M Wadhwa, G Chauhan, K Roy, S Sahu… - Frontiers in Cellular …, 2018 - frontiersin.org
Background: Sleep deprivation (SD) plagues modern society due to the professional
demands. It prevails in patients with mood and neuroinflammatory disorders. Although …