Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function
The purpose of this paper is to provide an integrative review and offer novel insights
regarding human research with classic psychedelics (classic hallucinogens), which are …
regarding human research with classic psychedelics (classic hallucinogens), which are …
Ketamine and depression: a narrative review
A Corriger, G Pickering - Drug design, development and therapy, 2019 - Taylor & Francis
Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …
be reduced within several weeks after the start of conventional antidepressants, but …
Targeting glutamate signalling in depression: progress and prospects
Major depressive disorder (MDD) is severely disabling, and current treatments have limited
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
Ketamine treatment for depression: a review
This manuscript reviews the clinical evidence regarding single-dose intravenous (IV)
administration of the novel glutamatergic modulator racemic (R, S)-ketamine (hereafter …
administration of the novel glutamatergic modulator racemic (R, S)-ketamine (hereafter …
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
Maintaining research and development (R&D) productivity at a sustainable level is one of
the main challenges currently facing the pharmaceutical industry. In this article, we discuss …
the main challenges currently facing the pharmaceutical industry. In this article, we discuss …
Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
JW Murrough, DV Iosifescu, LC Chang… - American Journal of …, 2013 - Am Psychiatric Assoc
Objective Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has
shown rapid antidepressant effects, but small study groups and inadequate control …
shown rapid antidepressant effects, but small study groups and inadequate control …
Kynurenines in the mammalian brain: when physiology meets pathology
R Schwarcz, JP Bruno, PJ Muchowski… - Nature Reviews …, 2012 - nature.com
The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3 …
degraded to several other neuroactive compounds, including kynurenic acid, 3 …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
The neurobiology of anhedonia and other reward-related deficits
A Der-Avakian, A Markou - Trends in neurosciences, 2012 - cell.com
Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major
depression, schizophrenia and other neuropsychiatric disorders. Over the past three …
depression, schizophrenia and other neuropsychiatric disorders. Over the past three …