The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Tumor cells are characterized by overexpressed tumor-associated antigens or mutated
neoantigens, which are expressed on the cell surface or intracellularly. One strategy of …

Pathogenic α-synuclein (α-syn) is a prion-like protein that drives the pathogenesis of Lewy
Body Dementia (LBD) and Parkinson's Disease (PD). To target pathogenic α-syn preformed …

Pancreatic cancer is an aggressive cancer with a dismal prognosis. This is due to the
difficulty to detect the disease at an early and curable stage. In addition, only limited …

There is no doubt that today's life sciences would look very different without the availability of
millions of research antibody products. Nevertheless, the use of antibody reagents that are …

Introduction Being an inherited neurodegenerative disease with an identifiable genetic
defect, Huntington's disease (HD) is a suitable candidate for early intervention, possibly …

Single-domain antibodies, derived from camelid heavy antibodies (nanobodies) or shark
variable new antigen receptors, have attracted increasing attention in recent years due to …

For decades antibodies were largely thought to provide protection in extracellular spaces
alone, mediating their effector functions by mechanisms such as entry-blocking, complement …

Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and
metastasis. The mechanisms that drive PRL-3's oncogenic functions are not well …

Delivering macromolecules into the cytosol or nucleus is possible in vitro for DNA, RNA and
proteins, but translation for clinical use has been limited. Therapeutic delivery of …