The use of fungal cultures have been well documented in human history. Although its used
in healthcare, like penicillin and statins, have saved countless of lives, but there is still no …

Hepatitis B remains one of the major global health problems more than 40 years after the
identification of human hepatitis B virus (HBV) as the causative agent. A critical turning point …

Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …

Recombinant protein subunit vaccines are formulated using defined protein antigens that
can be produced in heterologous expression systems. The methylotrophic yeast Pichia …

Vaccination is of paramount importance to global health. With the advent of the more recent
pandemics, the urgency to expand the range has become even more evident. However, the …

Objectives Recombinant protein subunit vaccines are formulated using protein antigens that
have been synthesized in heterologous host cells. Several host cells are available for this …

The increasing demand for recombinant vaccine antigens or immunotherapeutic molecules
calls into question the universality of current protein expression systems. Vaccine production …

The production of virus-like particles (VLPs) has gained importance over the last few years
owing to the benefits they provide compared to conventional vaccines. The …

The methylotrophic yeast Pichia pastoris is a widely used, well established protein
expression system for the production of biopharmaceutical and industrial enzymes. It is by …

Background In yeast, recombinant membrane proteins including viral scaffold proteins used
for the formation of enveloped Virus-like particles (eVLPs) typically accumulate …