Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility

A Ramos, K Ishizuka, A Hayashida, H Namkung… - Molecular …, 2024 - nature.com
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular
level. In a mouse model under subacute cellular stress in which deficits in rule shifting tasks …

The nuclear GAPDH-HMGB cascade in cortical microglia regulates cognitive flexibility

A Ramos, K Ishizuka, H Namkung, LN Hayes, A Saito… - bioRxiv, 2022 - biorxiv.org
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular
level. In a mouse model under subacute stress in which deficits in rule shifting tasks were …