Challenges and opportunities in metastatic breast cancer treatments: Nano-drug combinations delivered preferentially to metastatic cells may enhance therapeutic …

J Yu, Q Mu, M Fung, X Xu, L Zhu, RJY Ho - Pharmacology & therapeutics, 2022 - Elsevier
Despite advances in breast cancer treatments and related 5-year survival outcomes,
metastatic breast cancer cures remain elusive. The current standard of care includes a …

Nano-based delivery systems for berberine: A modern anti-cancer herbal medicine

H Majidzadeh, M Araj-Khodaei, M Ghaffari… - Colloids and Surfaces B …, 2020 - Elsevier
Berberine (BBR) is an isoquinoline alkaloid belonging to the structural class of
protoberberines. BBR has been used in traditional medicine to treat diseases, such as type …

[HTML][HTML] Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer

M Zhang, E Liu, Y Cui, Y Huang - Cancer biology & medicine, 2017 - ncbi.nlm.nih.gov
Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and is crucial
to cancer metastasis and relapse. Combination therapy is an effective strategy for …

Rising horizon in circumventing multidrug resistance in chemotherapy with nanotechnology

H Choudhury, M Pandey, TH Yin, T Kaur, GW Jia… - Materials Science and …, 2019 - Elsevier
Multidrug resistance (MDR) is one of the key barriers in chemotherapy, leading to the
generation of insensitive cancer cells towards administered therapy. Genetic and epigenetic …

[HTML][HTML] Combination cancer therapy using chimeric antigen receptor-engineered natural killer cells as drug carriers

EL Siegler, YJ Kim, X Chen, N Siriwon, J Mac… - Molecular Therapy, 2017 - cell.com
The therapeutic limitations of conventional chemotherapeutic drugs include chemo-
resistance, tumor recurrence, and metastasis. Numerous nanoparticle-based active …

Preparation and characterization of stable nanoliposomal formulations of curcumin with high loading efficacy: in vitro and in vivo anti-tumor study

M Karimi, F Gheybi, P Zamani, M Mashreghi… - International journal of …, 2020 - Elsevier
Liposomal formulations were made using Solvent-assisted active loading technology
(SALT). Two formulations composed of HSPC: DPPG: Chol: DSPE-mPEG 2000 (PG …

Microneedle‐based generation of microbubbles in cancer tumors to improve ultrasound‐assisted drug delivery

A Zandi, MA Khayamian, M Saghafi… - Advanced …, 2019 - Wiley Online Library
Production of local microbubbles (MBs) with dense distribution in tumor environment is
achieved by developing an integrated electrochemical stimulator on a microfabricated …

Micelles of d-α-Tocopheryl Polyethylene Glycol 2000 Succinate (TPGS 2K) for Doxorubicin Delivery with Reversal of Multidrug Resistance

T Hao, D Chen, K Liu, Y Qi, Y Tian, P Sun… - … Applied Materials & …, 2015 - ACS Publications
The purpose of this study is to investigate the ability of doxorubicin (DOX)-loaded d-α-
tocopheryl polyethylene glycol 2000 succinate (TPGS 2K) micelles to overcome MDR in …

[HTML][HTML] Drug resistance reversal in ovarian cancer cells of paclitaxel and borneol combination therapy mediated by PEG-PAMAM nanoparticles

L Zou, D Wang, Y Hu, C Fu, W Li, L Dai, L Yang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Paclitaxel (PTX) is frequently suffered from multidrug resistance (MDR), resulting in lower
chemotherapeutic efficacy and even chemotherapy failure. To combine the P-glycolprotein …

Understanding the implications of co-delivering therapeutic agents in a nanocarrier to combat multidrug resistance (MDR) in breast cancer

AD Fulfager, KS Yadav - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Cancer is one of the leading causes of death worldwide. Breast cancer is the most prevalent
cancer amongst women which can be treated by chemotherapy. During chemotherapy …