Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

At least five muscarinic receptors genes have been cloned and expressed. Muscarinic
receptors act via activation of G proteins: m1, m3 and m5 muscarinic receptors couple to …

Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …

The striatum plays a central role in motor control and motor learning. Appropriate responses
to environmental stimuli, including pursuit of reward or avoidance of aversive experience all …

Abstract Knowledge of the distributions and functions of native m1–m5 muscarinic
acetylcholine receptors in tissues is limited. To characterize the family of m1–m5 proteins …

Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS where they
control a variety of neuronal functions. Due to their roles in a number of CNS processes …

The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a
promising new strategy with potential for developing novel treatments for a variety of central …

Muscarinic acetylcholine receptors (mAChRs; M1–M5) play key roles in regulating the
activity of many important functions of the central and peripheral nervous system. Because of …