Multiple sclerosis is a chronic disease of the CNS that leads to substantial disability in most
patients. The early phase is characterised by relapses and the later phase by progressive …

Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …

The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle
that play major roles in cortical activation, relaying sensory information to the higher cortical …

During the past 10 years, the intense involvement of the grey matter of the CNS in the
pathology of multiple sclerosis has become evident. On gross inspection, demyelination in …

Purpose To apply quantitative susceptibility mapping (QSM) in the basal ganglia of patients
with multiple sclerosis (MS) and relate the findings to R2* mapping with regard to the …

Objectives: Gray matter (GM) atrophy is common in multiple sclerosis (MS), as is cognitive
dysfunction. Understanding the exact relationship between atrophy and cognition requires …

Objective In multiple sclerosis (MS), cerebral gray matter (GM) atrophy correlates more
strongly than white matter (WM) atrophy with disability. The corresponding relationships in …

Objectives To identify MRI biomarkers associated with long-term disability progression in
patients with multiple sclerosis (MS), and to define the rate of evolution of global, tissue …

Background Recent studies of cortical pathology in secondary progressive multiple sclerosis
have shown that a more severe clinical course and the presence of extended subpial grey …

Introduction: Brain atrophy measurement in multiple sclerosis (MS) has become an
important outcome for determining patients at risk for developing physical and cognitive …