Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence
of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a …

Repetitive brain trauma is associated with a progressive neurological deterioration, now
termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in …

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a
common feature of numerous aging-related neurodegenerative diseases, including …

While the microtubule-binding capacity of the protein tau has been known for many years,
new functions of tau in signaling and cytoskeletal organization have recently emerged. In …