Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …

The NFAT signaling pathway regulates various aspects of cellular functions; NFAT acts as a
calcium sensor, integrating calcium signaling with other pathways involved in development …

Cancer is amenable to low-cost treatments, given that it has a significant metabolic
component, which can be affected through diet and lifestyle change at minimal cost. The …

Propranolol (PRO) is a well-known and widely used non-selective beta-adrenergic receptor
antagonist (beta-blocker), with a range of actions which are of interest in an oncological …

Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …

Serine is a non-essential amino acid that is critical for tumour proliferation and depletion of
circulating serine results in reduced tumour growth and increased survival in various cancer …

The complex tumor immune pathology requires a precise spatial‐control release of the
combination drugs, but most multi‐drug loaded nanoparticles release all drugs …

New therapies are urgently needed for hematologic malignancies, especially in patients with
relapsed acute myelogenous leukemia (AML) and multiple myeloma. We and others have …

Almost all deaths from breast cancer arise from metastasis of the transformed cells to other
sites in the body. Hence, uncovering a means of inhibiting breast cancer cell migration …