Drug development in cardiovascular disease is stagnating, with lack of efficacy and adverse
effects being barriers to innovation. Human genetics can provide compelling evidence of …

Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Background Some observational studies found that dyslipidaemia is a risk factor for non-
alcoholic fatty liver disease (NAFLD), and lipid-lowering drugs may lower NAFLD risk …

ARID1A, encoding a subunit of the SWI/SNF complex, is mutated in∼ 50% of clear cell
ovarian carcinoma (OCCC) cases. Here we show that inhibition of the mevalonate pathway …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

Background Prostate cancer (PrCa) is the second most prevalent malignancy in men
worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Cardiovascular disease (CVD) and cancer are the leading causes of death worldwide. With
an increasing number of the elderly population, and early cancer screening and treatment …

Evidence from preclinical studies suggests that the competitive HMG-CoA reductase
(HMGCR) inhibitors universally known as' statins,'in addition to being powerful drugs that …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …