Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …

Cancer cachexia (CC) is a multifactorial and complex syndrome experienced by up to 80%
of patients with cancer and implicated in∼ 40% of cancer-related deaths. Given its …

Cachexia is a major cause of morbidity and mortality in individuals with cancer and is
characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white …

Background Cytokines secreted in the tumor microenvironment function in cancer cachexia
(CC), a common clinicopathological syndrome associated with adipocyte wasting and …

Loss of muscle mass is a common manifestation of chronic disease. We find the canonical
Wnt pathway to be activated in mesenchymal progenitors (MPs) from cancer-induced …

Simple Summary Cachexia occurs in up to 80% of patients with cancer. Although cancer-
associated cachexia dramatically decreases overall survival and quality of life, it is often …

Abstract Growth differentiation factor 15 (GDF15), a member of the transforming growth
factor‑β family, is a stress‑induced cytokine. Under normal circumstances, the expression of …

Cancer-associated cachexia occurs in 50% to 80% of cancer patients and is responsible for
20% to 30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and …

Background Sarcopenia or visceral adipose tissue has been reported to be related to
pancreatic cancer prognosis. However, clinical relevance of the comprehensive analysis of …

Cancer-associated cachexia (CAC) is a critical contributor to pancreatic ductal
adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new strategies to …