Mycobacterium tuberculosis is a highly efficient pathogen, killing millions of infected people
annually. The capacity of M. tuberculosis to survive and cause disease is strongly correlated …

Pathogenic mycobacteria, including Mycobacterium tuberculosis, are phagocytosed by
macrophages but manage to survive within the mycobacterial phagosome. Recent work has …

Mycobacteria are intracellular pathogens that can invade and survive within host
macrophages, thereby creating a major health problem worldwide. The molecular …

Mycobacteria are intracellular pathogens that can survive within macrophage phagosomes,
thereby evading host defense strategies by largely unknown mechanisms. We have …

Pathogenic mycobacteria survive within macrophages by avoiding lysosomal delivery,
instead residing in mycobacterial phagosomes. Upon infection, the leukocyte-specific …

We previously showed that viable Mycobacterium tuberculosis (Mtb) bacilli contain distinct
ligands that activate cells via the mammalian Toll-like receptor (TLR) proteins TLR2 and …

The pathogenesis of mycobacterial infection is associated with an ability to interfere with
maturation of the phagosomal compartment after ingestion by macrophages. Identification of …

The phagosomes containing viable pathogenic mycobacteria, such as Mycobacterium (M.)
tuberculosis and Mycobacterium avium ssp. avium (M. avium), are known to be limited in …

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages
is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a …

Macrophage cell membranes were labeled with PKH26 and subsequently incubated with
latex beads to generate phagosomes surrounded by a red-fluorescent membrane suitable …