The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Drug resistance and tolerance in fungi

J Berman, DJ Krysan - Nature Reviews Microbiology, 2020 - nature.com
Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

Immune regulation by fungal strain diversity in inflammatory bowel disease

XV Li, I Leonardi, GG Putzel, A Semon, WD Fiers… - Nature, 2022 - nature.com
The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial
community colonizing the mammalian gastrointestinal tract and has an important role in …

[HTML][HTML] Candida albicans and oral carcinogenesis. A brief review

M Di Cosola, AP Cazzolla, IA Charitos, A Ballini… - Journal of Fungi, 2021 - mdpi.com
Current medical knowledge and research on patients' management are still evolving, and
several protocols on minimizing risk of infection by Candida spp. among the population have …

Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs

RT Todd, A Selmecki - Elife, 2020 - elifesciences.org
Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …

Changes in fungal taxonomy: mycological rationale and clinical implications

AM Borman, EM Johnson - Clinical Microbiology Reviews, 2023 - Am Soc Microbiol
Numerous fungal species of medical importance have been recently subjected to and will
likely continue to undergo nomenclatural changes as a result of the application of molecular …

Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease

FM Anderson, ND Visser, KR Amses… - Plos …, 2023 - journals.plos.org
Candida albicans is a frequent colonizer of human mucosal surfaces as well as an
opportunistic pathogen. C. albicans is remarkably versatile in its ability to colonize diverse …

The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and …

VE Glazier, J Kramara, T Ollinger, NV Solis… - MBio, 2023 - Am Soc Microbiol
Candida albicans is a diploid human fungal pathogen that displays significant genomic and
phenotypic heterogeneity over a range of virulence traits and in the context of a variety of …

Interspecific hybridization as a driver of fungal evolution and adaptation

J Steensels, B Gallone, KJ Verstrepen - Nature Reviews Microbiology, 2021 - nature.com
Cross-species gene transfer is often associated with bacteria, which have evolved several
mechanisms that facilitate horizontal DNA exchange. However, the increased availability of …

[HTML][HTML] Immunosurveillance of Candida albicans commensalism by the adaptive immune system

M Swidergall, S LeibundGut-Landmann - Mucosal immunology, 2022 - Elsevier
The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing
the body surfaces and is involved in many key aspects of human physiology, while an …