Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

Promoting immune tolerance to transplanted organs can minimize the amount of
immunosuppressive drugs that patients need to take, reducing lifetime risks of mortality and …

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …

Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …

The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well
established; however, the precise alterations in Treg function in autoimmune individuals and …

CD4+ helper T (Th) cell subsets are critically involved in the pathogenesis of asthma. Naive
Th cells differentiate into different subsets under the stimulation of different sets of cytokines …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for
many types of cancer. Genetic disparities between donor and host can result in immune …

The microglial response to a pathological microenvironment is hallmarked by a change in
cellular morphology. Following a pathological stimulus, microglia become reactive and …

CD4+ CD25highFoxp3+ regulatory T-cells (Tregs) are functionally characterized for their
ability to suppress the activation of multiple immune cell types and are indispensable for …