Human pegivirus type 1: a common human virus that is beneficial in immune-mediated disease?

JT Stapleton - Frontiers in immunology, 2022 - frontiersin.org
Two groups identified a novel human flavivirus in the mid-1990s. One group named the virus
hepatitis G virus (HGV) and the other named it GB Virus type C (GBV-C). Sequence …

[HTML][HTML] Antiviral and anti-inflammatory drugs to combat COVID-19: Effects on cardiac ion channels and risk of ventricular arrhythmias

LX Cubeddu, D De la Rosa, M Ameruoso - BioImpacts: BI, 2022 - ncbi.nlm.nih.gov
Methods: We conducted a literature search on the drugs with purported or demonstrated
efficacy against COVID-19 disease, emphasizing the mechanisms by which anti-COVID-19 …

Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway

BL Kinlock, Y Wang, TM Turner, C Wang, B Liu - PloS one, 2014 - journals.plos.org
Background While it is accepted that viruses can enter epithelial cells by endocytosis, the
lack of an established biological mechanism for the trafficking of infectious virions through …

[图书][B] Epigenetic processes and evolution of life

J Švorcová, A Markoš - 2019 - taylorfrancis.com
The book covers the possible story of emergence of life and its subsequent evolution,
emphasizing the necessary evolutionary step negotiation of a common" language set" which …

Human pegivirus type 1 infection in Asia—A review of the literature

J Zimmerman, JT Blackard - Reviews in medical virology, 2022 - Wiley Online Library
The human pegivirus type 1 (HPgV‐1)—as known as hepatitis G virus and GB virus C—is a
common single‐stranded RNA flavivirus. Because few studies have demonstrated an …

Therapeutic exploitation of viral interference

I Kovesdi, T Bakacs - Infectious Disorders-Drug Targets …, 2020 - ingentaconnect.com
Viral interference, originally, referred to a state of temporary immunity, is a state whereby
infection with a virus limits replication or production of a second infecting virus. However …

Deep sequencing identifies two genotypes and high viral genetic diversity of human pegivirus (GB virus C) in rural Ugandan patients

RR Ghai, SD Sibley, M Lauck… - Journal of General …, 2013 - microbiologyresearch.org
Human pegivirus (HPgV), formerly 'GB virus C'or 'hepatitis G virus', is a member of the genus
Flavivirus (Flaviviridae) that has garnered significant attention due to its inhibition of HIV …

Prevalence of human pegivirus (HPgV) infection in patients carrying HIV‐1C or non‐C in southern Brazil

LD Da Mota, AS Nishiya… - Journal of Medical …, 2016 - Wiley Online Library
Previous studies have demonstrated that coinfection with HPgV is a protective factor for
human immunodeficiency virus (HIV)‐infected patients, leading to slower disease …

[HTML][HTML] Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors

AY Chowdhury, JE Tavis, SL George - Virology, 2014 - Elsevier
We previously found that human pegivirus (HPgV; formerly GBV-C) NS3 protease activity
inhibits Human Immunodeficiency Virus (HIV) replication in a CD4+ T cell line. Given the …

[HTML][HTML] Would the interference phenomenon be applied as an alternative option for prophylaxis against COVID-19?

MH Ahmadi - BioImpacts: BI, 2020 - pmc.ncbi.nlm.nih.gov
The coronavirus disease 2019 (COVID-19) is an emerged infectious disease characterized
by a severe pneumonia leading to death in some cases. Currently, no licensed vaccines …