Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

mRNA-based HIV-1 vaccines

S Ahmed, A Herschhorn - Clinical microbiology reviews, 2024 - journals.asm.org
The success of the Severe Acute Respiratory Syndrome Coronavirus 2 mRNA vaccines to
lessen/prevent severe COVID-19 opened new opportunities to develop RNA vaccines to …

Ultrasensitive quantification of HIV-1 cell-to-cell transmission in primary human CD4+ T cells measures viral sensitivity to broadly neutralizing antibodies

D Mazurov, A Herschhorn - Mbio, 2024 - Am Soc Microbiol
ABSTRACT HIV-1 can efficiently replicate by direct transmission from infected to uninfected
CD4+ T cells at confined local sites designated virological synapses (VSs). VSs are formed …

Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting …

J Jeffy, D Parthasarathy, S Ahmed, H Cervera-Benet… - Mbio, 2024 - Am Soc Microbiol
The envelope glycoprotein (Env) trimer on the surface of human immunodeficiency virus
type I (HIV-1) mediates viral entry into host CD4+ T cells and is the sole target of neutralizing …

[PDF][PDF] Dual Action Potential: Bromophenol in Combatting COVID-19 and Modulating ACE2-Mediated Circulatory Hemostasis: A Molecular Modeling Study

KT CİNİSLİ, A SHADIDIZAJI, B ÇINAR, M REZAİ… - 2024 - scholar.archive.org
The possible recurrent threat of the COVID-19pandemic driven by SARS-CoV-2
underscores the critical need for innovative pharmaceutical interventions targeting …