Chromatin accessibility profiling methods
L Minnoye, GK Marinov, T Krausgruber, L Pan… - Nature Reviews …, 2021 - nature.com
Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …
[HTML][HTML] Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies
Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very
heterogeneous biological and clinical behavior. The last decade has been remarkably …
heterogeneous biological and clinical behavior. The last decade has been remarkably …
Genomic profiling for clinical decision making in lymphoid neoplasms
L De Leval, AA Alizadeh, PL Bergsagel… - Blood, The Journal …, 2022 - ashpublications.org
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
SEdb 2.0: a comprehensive super-enhancer database of human and mouse
Y Wang, C Song, J Zhao, Y Zhang, X Zhao… - Nucleic Acids …, 2023 - academic.oup.com
Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
TP63, SOX2, and KLF5 establish a core regulatory circuitry that controls epigenetic and transcription patterns in esophageal squamous cell carcinoma cell lines
Background & Aims We investigated the transcriptome of esophageal squamous cell
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …
carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and …
Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance
DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that
the local chromatin context affects the pathway choice, but the underlying principles are …
the local chromatin context affects the pathway choice, but the underlying principles are …
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …
Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia
J Lu, E Cannizzaro, F Meier-Abt, S Scheinost… - Nature cancer, 2021 - nature.com
Chronic lymphocytic leukemia (CLL) has a complex pattern of driver mutations and much of
its clinical diversity remains unexplained. We devised a method for simultaneous subgroup …
its clinical diversity remains unexplained. We devised a method for simultaneous subgroup …