Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

All living organisms must transmit genetic information through successive generations, and
all six eukaryotic supergroups utilize a mitotic spindle to accomplish this task. The mitotic …

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to
elongate in anaphase. However, although some candidate proteins are implicated in this …

Cytokinesis is the final event of the cell cycle dividing one cell into two daughter cells. The
protein regulator of cytokinesis (PRC) 1 is essential for cytokinesis and normal cell cleavage …

Haplotype analysis and targeted next-generation resequencing allowed us to identify a
mutation in the KIF23 gene and to show its association with an autosomal dominant form of …

Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-
translational modification involved in mitosis and cytokinesis. However, knowledge about α …

Mitotic cell divisions ensure stable transmission of genetic information from a mother to
daughter cells in a series of generations. To ensure this crucial task is accomplished, the cell …

A critical structure poised to coordinate chromosome segregation with division plane
specification is the central spindle that forms between separating chromosomes after …

Cell division entails a marked reorganization of the microtubule network to form the spindle,
a molecular machine that ensures accurate chromosome segregation to the daughter cells …