Twenty years of equine piroplasmosis research: global distribution, molecular diagnosis, and phylogeny

S Tirosh-Levy, Y Gottlieb, LM Fry, DP Knowles… - Pathogens, 2020 - mdpi.com
Equine piroplasmosis (EP), caused by the hemoparasites Theileria equi, Theileria haneyi,
and Babesia caballi, is an important tick-borne disease of equines that is prevalent in most …

Open source drug discovery with the malaria box compound collection for neglected diseases and beyond

WC Van Voorhis, JH Adams, R Adelfio… - PLoS …, 2016 - journals.plos.org
A major cause of the paucity of new starting points for drug discovery is the lack of
interaction between academia and industry. Much of the global resource in biology is …

Discovering the in vitro potent inhibitors against Babesia and Theileria parasites by repurposing the Malaria Box: A review

MA Rizk, SAES El-Sayed, S El-Khodery… - Veterinary …, 2019 - Elsevier
There is an innovative approach to discovering and developing novel potent and safe anti-
Babesia and anti-Theileria agents for the control of animal piroplasmosis. Large-scale …

Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo

AM Beshbishy, GES Batiha, N Yokoyama, I Igarashi - Parasites & vectors, 2019 - Springer
Background There are no effective vaccines against Babesia and Theileria parasites;
therefore, therapy depends heavily on antiprotozoal drugs. Treatment options for …

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

A Ramaprasad, PC Burda, E Calvani, AJ Sait… - Elife, 2022 - elifesciences.org
The malaria parasite Plasmodium falciparum synthesizes significant amounts of
phospholipids to meet the demands of replication within red blood cells. De novo …

Clofazimine Inhibits the Growth of Babesia and Theileria Parasites In Vitro and In Vivo

B Tuvshintulga, M AbouLaila… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
The present study evaluated the growth-inhibitory effects of clofazimine, currently used for
treating leprosy, against Babesia bovis, B. bigemina, B. caballi, and Theileria equi in in vitro …

Myrrh Oil in Vitro Inhibitory Growth on Bovine and Equine Piroplasm Parasites and Babesia microti of Mice

M AbouLaila, SAES El-Sayed, MA Omar… - Pathogens, 2020 - mdpi.com
The present experimental study was conducted for the assessment of the efficacy of in vitro
inhibition of myrrh oil on the propagation of Babesia bovis, B. divergens, B. bigemina …

Evaluation of in vitro inhibitory effect of enoxacin on Babesia and Theileria parasites

MA Omar, A Salama, A Elsify, MA Rizk… - Experimental …, 2016 - Elsevier
Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent
(fluoroquinolones) structurally related to nalidixic acid used mainly in the treatment of urinary …

The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death

AL Legarda-Ceballos, J Rojas-Caraballo… - Acta tropica, 2016 - Elsevier
Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the
drug of choice for the treatment. However, the concerns about relying treatment on a single …

In vitro antiparasitic effects of six beverages on the growth of Babesia and Theileria parasites

MR ABOULAILA, MA RIZK, S EL-SAYED… - Annals of …, 2018 - ambs-journal.co.uk
Introduction: To evaluate the inhibitory effects of the decoction of green tea, black tea, instant
coffee, hibiscus, cinnamon, and peppermint on the in vitro growth of Babesia bovis, Babesia …