Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …

Diabetic cystopathy is a well-recognized complication of diabetes mellitus, which usually
develops in middle-aged or elderly patients with long-standing and poorly controlled …

Gene transfer is an increasingly utilized approach for research and clinical applications
involving the central nervous system (CNS). Vectors for gene transfer can be as simple as …

Endogenous opiate peptides acting pre-and post-synaptically in the dorsal horn of spinal
cord inhibit transmission of nociceptive stimuli. We transfected neurons of the dorsal root …

Purpose: It has been proposed that a deficiency in the axonal transport of nerve growth
factor (NGF) may have an important role in inducing diabetic neuropathy, which contributes …

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of
molecular biology and the new tools derived from molecular genetics have revolutionized …

Rheumatoid arthritis is characterized by erosive inflammation of the joints, new bone
proliferation, and ankylosis, leading to severely reduced locomotion and intense chronic …

Accumulation of insoluble aggregates of amyloid-β peptide (Aβ), a cleavage product of
amyloid precursor protein (APP), is thought to be central to the pathogenesis of Alzheimer's …

Peripheral neuropathy is a common and debilitating complication of diabetes. In animal
models, neurotrophic factors can prevent progression of the neuropathy, but adverse effects …

Injuries to the adult mammalian spinal cord often lead to severe damage to both ascending
(sensory) pathways and descending (motor) nerve pathways without the perspective of …