Chitosan nanoparticles at the biological interface: implications for drug delivery

N Aibani, R Rai, P Patel, G Cuddihy, EK Wasan - Pharmaceutics, 2021 - mdpi.com
The unique properties of chitosan make it a useful choice for various nanoparticulate drug
delivery applications. Although chitosan is biocompatible and enables cellular uptake, its …

Intestinal permeation enhancers for oral peptide delivery

S Maher, RJ Mrsny, DJ Brayden - Advanced drug delivery reviews, 2016 - Elsevier
Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to
improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation …

Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

MC Chen, FL Mi, ZX Liao, CW Hsiao, K Sonaje… - Advanced drug delivery …, 2013 - Elsevier
Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal
absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive …

Biocompatibility of chitosan carriers with application in drug delivery

S Rodrigues, M Dionísio, C Remunan Lopez… - Journal of functional …, 2012 - mdpi.com
Chitosan is one of the most used polysaccharides in the design of drug delivery strategies
for administration of either biomacromolecules or low molecular weight drugs. For these …

Polymeric nanoparticle drug delivery technologies for oral delivery applications

EM Pridgen, F Alexis, OC Farokhzad - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Many therapeutics are limited to parenteral administration. Oral administration
is a desirable alternative because of the convenience and increased compliance by …

Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin

Z He, JL Santos, H Tian, H Huang, Y Hu, L Liu… - Biomaterials, 2017 - Elsevier
Controlled delivery of protein would find diverse therapeutic applications. Formulation of
protein nanoparticles by polyelectrolyte complexation between the protein and a natural …

In vitro and in vivo models for the study of oral delivery of nanoparticles

JM Gamboa, KW Leong - Advanced drug delivery reviews, 2013 - Elsevier
Oral delivery is an attractive route to deliver therapeutics via nanoparticles due to its ease of
administration and patient compliance. This review discusses laboratory techniques for …

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures

K Murugan, YE Choonara, P Kumar… - International journal …, 2015 - Taylor & Francis
Cellular internalization and trans-barrier transport of nanoparticles can be manipulated on
the basis of the physicochemical and mechanical characteristics of nanoparticles. Research …

Dual chitosan/albumin-coated alginate/dextran sulfate nanoparticles for enhanced oral delivery of insulin

M Lopes, N Shrestha, A Correia, MA Shahbazi… - Journal of controlled …, 2016 - Elsevier
The potential of nanoparticles (NPs) to overcome the barriers for oral delivery of protein
drugs have led to the development of platforms capable of improving their bioavailability …

Marine polysaccharides in pharmaceutical applications: Fucoidan and chitosan as key players in the drug delivery match field

AI Barbosa, AJ Coutinho, SA Costa Lima, S Reis - Marine Drugs, 2019 - mdpi.com
The use of marine-origin polysaccharides has increased in recent research because they
are abundant, cheap, biocompatible, and biodegradable. These features motivate their …