Vascular complications contribute significantly to morbidity and mortality of diabetes mellitus.
The primary cause of vascular complications in diabetes mellitus is hyperglycaemia …

Liver X receptors (LXRs) are master regulators of metabolism and have been studied for
their pharmacological potential in vascular and metabolic disease. Besides their established …

Background Endothelial dysfunction has been suggested as a possible causal link between
hyperglycemia and microvascular complications in diabetes mellitus. The effect of metformin …

Myocardial injury and dysfunction are critical manifestations of sepsis. Previous studies have
reported that liver X receptor (LXR) activation is protective during sepsis. However, whether …

Activation of Liver X receptors (LXRs), key transcriptional regulators of glucose metabolism,
normalizes glycemia and improves insulin sensitivity in rodent models with insulin …

Autophagy is involved in the development of numerous illnesses, including
ischemia/reperfusion (I/R). Endothelial nitric oxide synthase (eNOS) participates in the …

Endothelial progenitor cell (EPC) dysfunction contributes to diabetes‐induced delay in
endothelium repair after vessel injury, prominently associated with diabetic cardiovascular …

Vascular endothelial injury is a major cause of many cardiovascular diseases. The
proliferation and migration of endothelial progenitor cells (EPCs) play a pivotal role in …

Liver X receptor alpha (LXRα) is a nuclear receptor involved in cholesterol homeostasis.
Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa and a well …

Background In EMS‐associated laminitis, laminar failure may occur in response to energy
failure related to insulin resistance (IR) or to the effect of hyperinsulinemia on laminar tissue …